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Dr. Blake Clarke was born and raised in St. Louis, Missouri. He attended Saint Louis University, where he met his wife, before earning his Doctor of Dental Surgery degree from the University of Missouri–Kansas City. After dental school, he completed his specialty residency training in Endodontics at the University of Minnesota, where he served as Chief Resident.

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Dr. Clarke is Board Certified by the American Board of Endodontics, a distinction earned by fewer than 25% of endodontists. He is the first author of two publications in the Journal of Endodontics and has co-authored other published papers. He serves on the Resident & New Practitioner Committee for the American Association of Endodontists (AAE), reflecting his commitment to advancing the specialty through research, leadership, and professional service. Dr. Clarke's research has focused on the root canal microbiome, endodontic infections, and the clinical management of complex endodontic cases. This research informs his clinical approach to diagnosis and treatment planning to preserve natural teeth.

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He now resides in St. Louis with his wife and their three dogs. He enjoys playing and watching hockey, traveling, spending time with his dogs, and trying new restaurants.

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Publications 

Taxonomy and Virulence Factors in the Root Canal Microbiome: Metagenomic Insights by Lesion Size and Clinical Factors in Primary Endodontic Infections 

Journal of Endodontics, 2026

 

Surgical and Nonsurgical Endodontic Treatment of a Patient with Vitamin D-resistant Rickets and Extraoral Sinus Tract: A Case Report

Journal of Endodontics, 2026

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The Effect of Endodontic Disinfection on Microbial Reduction and Biodiversity of Root Canal Systems with Necrotic Pulps (Co-author)

Journal of Endodontics, 2026

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Endodontic Periodontic Lesions (Co-author)
Communiqué, American Association of Endodontists, November 2024